reprodICU is a freely accessible pipeline, streamlining the creation of a harmonized critical care dataset, including data from up to 470k ICU admissions from multiple healthcare centers across the US and Europe. In this pipeline, reprodICU harmonizes data from the following publicly available ICU datasets, which were previously published by others: AmsterdamUMCdb, eICU-CRD, HiRID, MIMIC-III, MIMIC-IV, NWICU, SICb.
As part of the Charité Outcomes Research Repository (CORR), the pipeline was developed by the Institute of Medical Informatics (IMI) at Charité - Universitätsmedizin Berlin.
The dataset created by running the pipeline contains de-identified demographic information and a total of 136 routinely collected physiological variables, diagnostic test results and treatment parameters from almost 350k patients during the period from 2001 to 2022.
reprodICU integrates 469,822 ICU admissions from seven major public datasets across four countries, creating the largest harmonized ICU dataset publicly available. This breadth enables cross-institutional and cross-national studies that were previously impractical due to data incompatibility.
reprodICU is harmonized using established clinical vocabularies (e.g., SNOMED, LOINC, RxNorm) and broadly follows the structure of the German Medical Informatics Initiative modules to ensure interoperability. Crucially, the project applies minimal preprocessing to preserve source fidelity and maintain compatibility with the original datasets.
The project includes a large, curated catalog of clinical variables, ranging from advanced ventilator metrics to dozens of mortality and severity scoring systems (e.g., SOFA, APACHE, MODS, NEWS, SAPS). These ready-to-use components eliminate the need for researchers and developers to manually redefine or look up formulas, making it easier and faster to build robust analyses or models.
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